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Broad Institute Inc gsea linux_4.1.0
Transcriptome sequencing analysis after c-Myc silencing (A) GO analysis of downregulated DEGs. (B) RT-PCR-based validation of the downregulated DEGs associated with DNA replication and repair in U2932 cells treated with PBS (control), γPNA2-NLS, and Scr-γPNA3-NLS (8 μM) for 72 h. Graphs show mean ± SEM (n = 3); p value for unpaired two-sample t test. (C) Hierarchical clustering analysis of DEGs after treatment of U2932 cells with γPNA2-NLS and siRNA compared with PBS treatment. (D) Enrichment plots for the top three datasets enriched in <t>GSEA,</t> showing NES and normalized p value.
Gsea Linux 4.1.0, supplied by Broad Institute Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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gsea linux_4.1.0 - by Bioz Stars, 2026-09
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Transcriptome sequencing analysis after c-Myc silencing (A) GO analysis of downregulated DEGs. (B) RT-PCR-based validation of the downregulated DEGs associated with DNA replication and repair in U2932 cells treated with PBS (control), γPNA2-NLS, and Scr-γPNA3-NLS (8 μM) for 72 h. Graphs show mean ± SEM (n = 3); p value for unpaired two-sample t test. (C) Hierarchical clustering analysis of DEGs after treatment of U2932 cells with γPNA2-NLS and siRNA compared with PBS treatment. (D) Enrichment plots for the top three datasets enriched in GSEA, showing NES and normalized p value.

Journal: Cell Reports Medicine

Article Title: Antitumor efficacy of a sequence-specific DNA-targeted γPNA-based c-Myc inhibitor

doi: 10.1016/j.xcrm.2023.101354

Figure Lengend Snippet: Transcriptome sequencing analysis after c-Myc silencing (A) GO analysis of downregulated DEGs. (B) RT-PCR-based validation of the downregulated DEGs associated with DNA replication and repair in U2932 cells treated with PBS (control), γPNA2-NLS, and Scr-γPNA3-NLS (8 μM) for 72 h. Graphs show mean ± SEM (n = 3); p value for unpaired two-sample t test. (C) Hierarchical clustering analysis of DEGs after treatment of U2932 cells with γPNA2-NLS and siRNA compared with PBS treatment. (D) Enrichment plots for the top three datasets enriched in GSEA, showing NES and normalized p value.

Article Snippet: GSEA (Linux_4.1.0) , Broad Institute , N/A.

Techniques: Sequencing, Reverse Transcription Polymerase Chain Reaction, Biomarker Discovery, Control